advanced sleep phase syndrome การใช้

• Mutations and variants of the CK1? phosphorylation site of PER2 are associated with cases of Familial Advanced Sleep Phase Syndrome ( FASPS ).
• In humans, mutations affecting the PER2 phosphorylation site of the CK1? gene results in Familial advanced sleep phase syndrome ( FASPS ).
• A role of CKI? has also been seen in humans related to Familial Advanced Sleep Phase Syndrome, in which individuals have a much shorter period than the typical human.
• A defect in the human homologue of the " Drosophila " " period " gene was identified as a cause of the sleep disorder FASPS ( Familial advanced sleep phase syndrome ), underscoring the conserved nature of the molecular circadian clock through evolution.